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小鼠妊娠晚期骨骼肌和子宫中能量代谢的酶活性。

Enzyme activities of energy metabolism in skeletal muscle, and in the uterus, during late pregnancy in the mouse.

作者信息

Orlander J

出版信息

Acta Physiol Scand. 1984 Feb;120(2):305-10. doi: 10.1111/j.1748-1716.1984.tb00138.x.

DOI:10.1111/j.1748-1716.1984.tb00138.x
PMID:6711342
Abstract

Three hindleg muscles (white and red quadriceps, soleus), and uterine tissue, from late pregnant NMRI mice were analyzed for selected enzyme activities of energy metabolism. In addition, skeletal muscle fibre type distribution and fibre diameters were estimated in some animals. No differences between pregnant and non-pregnant animals were found for any enzyme in any of the tissues. Neither were there any differences in muscle morphology. It was concluded, that the increased work load, and altered plasma substrate profile, during late pregnancy do not induce metabolic or morphological adaptations in skeletal muscle. Furthermore, the smooth muscle of the murine myometrium does not increase its metabolic capacity in preparation for parturition, suggesting that the base-line metabolic capacity is sufficient for the work involved. The morphological and metabolic characteristics of the three skeletal muscles were similar to those in the rat. Compared with these muscles, the uterus had a low metabolic capacity, and appeared to rely predominantly on fatty acid oxidation.

摘要

对怀孕后期的NMRI小鼠的三条后肢肌肉(白色和红色股四头肌、比目鱼肌)以及子宫组织进行了能量代谢相关酶活性的分析。此外,还对部分动物的骨骼肌纤维类型分布和纤维直径进行了评估。在任何组织中,任何一种酶在怀孕和未怀孕的动物之间均未发现差异。肌肉形态也没有任何差异。得出的结论是,怀孕后期增加的工作量和改变的血浆底物谱并未诱导骨骼肌出现代谢或形态学适应。此外,小鼠子宫肌层的平滑肌在为分娩做准备时并未增加其代谢能力,这表明基线代谢能力足以满足所涉及的工作。这三条骨骼肌的形态和代谢特征与大鼠相似。与这些肌肉相比,子宫的代谢能力较低,并且似乎主要依赖脂肪酸氧化。

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