El-Kashef H A, Badary O, El-Mazar M M, Al-Shabana O, Al-Bekiri A
Dept. of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
J Exp Clin Cancer Res. 1998 Sep;17(3):259-62.
The effects of Ehrlich Ascites Carcinoma (EAC) cells on the responses of isolated uterine smooth muscles obtained from normal non-pregnant and pregnant mice to oxytocin and acetylcholine (ACh) were investigated. The contractions of normal uterine smooth muscles to oxytocin "0.1, 1 and 10 mU" and to ACh "0.1, 1 and 10 uM" were significantly reduced in the presence of EAC cells. On the other hand, induction of pregnancy in control non-tumor bearing mice significantly increases the sensitivity of the uterine smooth muscles to oxytocin as well as to ACh. In tumor bearing mice, the induction of pregnancy significantly reduced the sensitivity of the uterine smooth muscles to oxytocin and ACh when compared with the uterine muscles obtained from pregnant non-tumor bearing mice. The results of the present study indicate that the presence of tumor cells decreases the responses of the uterine smooth muscles to oxytocin and ACh, while pregnancy increases the uterine contractions induced by oxytocin and ACh. Furthermore, induction of pregnancy in tumor bearing animals reduces the responsiveness of uterine smooth muscles to oxytocin and ACh.
研究了艾氏腹水癌细胞（EAC）对从正常未孕和孕鼠分离的子宫平滑肌对催产素和乙酰胆碱（ACh）反应的影响。在存在EAC细胞的情况下，正常子宫平滑肌对催产素“0.1、1和10 mU”以及对ACh“0.1、1和10 μM”的收缩显著降低。另一方面，在对照未荷瘤小鼠中诱导怀孕显著增加了子宫平滑肌对催产素以及对ACh的敏感性。在荷瘤小鼠中，与从怀孕未荷瘤小鼠获得的子宫肌肉相比，诱导怀孕显著降低了子宫平滑肌对催产素和ACh的敏感性。本研究结果表明，肿瘤细胞的存在降低了子宫平滑肌对催产素和ACh的反应，而怀孕增加了催产素和ACh诱导的子宫收缩。此外，在荷瘤动物中诱导怀孕降低了子宫平滑肌对催产素和ACh的反应性。
