Ramsdell W M, Shulman R J, Lifschitz C H
Am J Dis Child. 1984 May;138(5):500-1. doi: 10.1001/archpedi.1984.02140430076020.
The association of perianal fistulas and Crohn's disease is well recognized. The appearance of lesions distant from the anal area is, however, uncommon. A young girl appeared with a history of weight loss and extensive mucocutaneous ulcerations. Diarrhea subsequently developed. Colonoscopy revealed friability, edema, and ulcerations. A crypt abscess was found in colonic biopsy specimens. Treatment with prednisolone acetate and sulfasalazine resulted in prompt improvement. A skin biopsy done initially and repeated colon biopsy three months later demonstrated granulomas, consistent with Crohn's disease. The literature regarding skin lesions in association with Crohn's disease is reviewed and the importance of recognizing the cutaneous manifestations of Crohn's disease is emphasized.
肛周瘘管与克罗恩病的关联已得到充分认识。然而，肛门区域以外部位出现病变的情况并不常见。一名年轻女孩出现体重减轻和广泛黏膜皮肤溃疡病史。随后出现腹泻。结肠镜检查显示肠黏膜脆、水肿和溃疡。结肠活检标本中发现隐窝脓肿。使用醋酸泼尼松龙和柳氮磺胺吡啶治疗后症状迅速改善。最初进行的皮肤活检以及三个月后重复进行的结肠活检均显示有肉芽肿，符合克罗恩病。本文回顾了与克罗恩病相关的皮肤病变的文献，并强调了认识克罗恩病皮肤表现的重要性。
