Markwalder K, Hess K, Valavanis A, Witassek F
Am J Trop Med Hyg. 1984 Mar;33(2):273-80. doi: 10.4269/ajtmh.1984.33.273.
Two patients with cerebral cysticercosis are described: one with a long-standing infection with multiple intracerebral calcifications, and one who had become infected only recently. Treatment with praziquantel 50 mg/kg body weight daily for 14 days resulted in clinical and radiological improvement in the first patient, although she obviously still harbored a number of viable non-calcified parasites. The second patient was completely cured by the same praziquantel regimen. Both patients needed temporary corticosteroid treatment to suppress development of intracranial hypertension. Computerized tomographic scanning and regular measurement of serum antibody titers against cysticercal and echinococcal antigen seem appropriate methods for follow-up of the effect of chemotherapy.
一名患有长期感染，脑内有多处钙化；另一名则是近期才感染。第一名患者每天服用50mg/kg体重的吡喹酮，持续14天，临床和影像学表现有所改善，尽管她显然仍有许多存活的非钙化寄生虫。第二名患者采用相同的吡喹酮治疗方案后完全治愈。两名患者都需要临时使用皮质类固醇治疗以抑制颅内高压的发展。计算机断层扫描和定期测量血清中针对囊尾蚴和棘球蚴抗原的抗体滴度似乎是随访化疗效果的合适方法。
