Wall M A, Misley M C, Dickerson D
Am Rev Respir Dis. 1984 Apr;129(4):557-62.
The purpose of this study was to examine the variability and possible uses of partial maximal expiratory flow-volume curves as a measurement of lung function in young children. Repeated partial flow-volume curves followed by measurement of resting lung volume were obtained from 45 healthy children and 12 with generally mild lung disease caused by cystic fibrosis; the age range was 3 to 6 yr. At each test session, each child completed 3 runs; for each run, values of functional residual capacity, maximal flow at functional residual capacity, and maximal flow compensated for lung size were obtained. Within-subject, day-to-day, and among-subject variabilities in the healthy group were very close to those reported for similar flow rates and lung volume in older subjects who are able to produce a full forced vital capacity. When compensated for lung volume, healthy boys had significantly lower flow rates than did girls. Test sensitivity and specificity were such that the cystic fibrosis and healthy groups were easily discernible. Among-subject variability of flow rates in healthy children was large enough to make the accurate detection of mild airways dysfunction in any given individual difficult.
本研究的目的是检验部分最大呼气流量-容积曲线作为幼儿肺功能测量指标的变异性及可能用途。对45名健康儿童和12名患有由囊性纤维化引起的一般轻度肺部疾病的儿童进行了重复的部分流量-容积曲线测试，随后测量静息肺容积；年龄范围为3至6岁。在每次测试期间，每个儿童完成3次测试；每次测试时，获取功能残气量、功能残气量时的最大流量以及根据肺大小校正后的最大流量值。健康组的受试者内、每日及受试者间变异性与能够完成完整用力肺活量的年长受试者中类似流速和肺容积所报告的变异性非常接近。校正肺容积后，健康男孩的流速显著低于女孩。测试的敏感性和特异性使得囊性纤维化组和健康组易于区分。健康儿童流速的受试者间变异性足够大，以至于在任何给定个体中准确检测轻度气道功能障碍都很困难。
