Ehmann W D, Alauddin M, Hossain T I, Markesbery W R
Ann Neurol. 1984 Jan;15(1):102-4. doi: 10.1002/ana.410150119.
The trace element content of the brain of two patients with Pick's disease examined postmortem was studied using instrumental neutron activation analysis. Results showed significant increases in chlorine, iron, manganese, sodium, and phosphorus and significant decreases in chromium, cesium, rubidium, and selenium and in the mean freeze-dried to wet-weight ratio for patients with Pick's disease compared with control patients. Brain zinc content was not elevated in the two patients, a finding that fails to support the hypothesis that elevated zinc levels play a role in the pathogenesis of Pick's disease.
采用仪器中子活化分析法研究了两名死后检查的匹克氏病患者大脑中的微量元素含量。结果显示，与对照患者相比，匹克氏病患者的氯、铁、锰、钠和磷显著增加，铬、铯、铷和硒以及平均冻干与湿重比显著降低。两名患者的脑锌含量并未升高，这一发现不支持锌水平升高在匹克氏病发病机制中起作用的假说。
