Sakamoto G
Gan To Kagaku Ryoho. 1984 Mar;11(3 Pt 2):703-8.
Breast cancer among Japanese females was characterized by a relatively low incidence and good prognosis. But recently its morbidity is increasing and its biological behavior is changing. The chronological changes and prospective features of breast cancer among Japanese females are follows: 1. Increase of morbidity and mortality 2. Increase of the ratio of poorly differentiated carcinoma and decrease of well differentiated carcinoma 3. Increase of the incidence of lobular carcinoma 4. Increase of the case of the aged females Above items show that breast cancer among Japanese females is becoming westernizing. The case-control study on "breast cancer occurrence and obesity" shows that an obesity of the aged is a significant high risk factor for breast cancer occurrence. There fore, it would be effective that the prevention of overweight at the postmenopausal women to reduce the breast cancer occurrence. The chronological rise of overall 10-year survival rate of operated breast cancer is caused by increasing the ratio of early stage cases. Suggesting an importance of regular self-examination of the breast. Furthermore, it is important to establish an adjuvant therapy without causing side effect for curatively operated cases. Concerning the cancer of the uterus among Japanese females, the chronological occurrence rate of endometrial cancer is increasing, while the death rate of cervical cancer is decreasing.
日本女性乳腺癌的特点是发病率相对较低且预后良好。但近年来其发病率在上升，生物学行为也在改变。日本女性乳腺癌的时间变化和前瞻性特征如下：1. 发病率和死亡率上升；2. 低分化癌比例增加，高分化癌比例下降；3. 小叶癌发病率上升；4. 老年女性病例增加。上述情况表明日本女性乳腺癌正呈现西方化趋势。关于“乳腺癌发生与肥胖”的病例对照研究表明，老年肥胖是乳腺癌发生的一个显著高危因素。因此，绝经后女性预防超重对降低乳腺癌发生率是有效的。手术治疗的乳腺癌患者总体10年生存率随时间上升是由于早期病例比例增加。这表明乳房定期自我检查很重要。此外，为根治性手术病例建立无副作用的辅助治疗也很重要。关于日本女性子宫癌，子宫内膜癌的发病时间发生率在上升，而宫颈癌的死亡率在下降。
