Sakamoto G, Sugano H
Department of Pathology, Cancer Institute, Tokyo, Japan.
Breast Cancer Res Treat. 1991 May;18 Suppl 1:S81-3. doi: 10.1007/BF02633534.
Breast cancer among Japanese females is characterized by its relatively low incidence and better prognosis than among Caucasian females. The annual mortality due to breast cancer among Japanese is about one-fifth that among Caucasians. Comparison of case distribution by histological type indicates that the ratio of well-differentiated carcinoma is slightly higher among Japanese, while the ratio of poorly differentiated carcinoma is slightly higher among Caucasian females. It is noteworthy that the incidence of in situ and invasive lobular carcinoma among Japanese is much lower than among Caucasian females. The age distribution shows that breast cancer is more frequent among middle-aged females in Japan, but more common among aged females in the West. Breast cancer among Japanese females shows a better prognosis than among Caucasian females as a whole, even with equal tumor size and lymph node metastasis. As mentioned above, the morbidity and mortality rates of breast cancer among Japanese females are very low, but recently, both morbidity and mortality rates in Japan have been steeply increasing. For example, the mortality rate of breast cancer in Japan almost doubled during the past 20 years. Moreover, biological behavior of breast cancer among Japanese females has been recently changing. Time-trend data clearly indicate that breast cancer in Japan in the future will be much more like that in the West, and nowadays it is already westernizing.
日本女性乳腺癌的特点是发病率相对较低，且预后比白种女性更好。日本因乳腺癌导致的年死亡率约为白种人的五分之一。按组织学类型对病例分布进行比较表明，日本高分化癌的比例略高，而白种女性中低分化癌的比例略高。值得注意的是，日本原位和浸润性小叶癌的发病率远低于白种女性。年龄分布显示，日本中年女性患乳腺癌更为常见，但在西方老年女性中更为普遍。即使肿瘤大小和淋巴结转移情况相同，日本女性乳腺癌的预后总体上也比白种女性更好。如上所述，日本女性乳腺癌的发病率和死亡率非常低，但最近，日本的发病率和死亡率都在急剧上升。例如，在过去20年里，日本乳腺癌的死亡率几乎翻了一番。此外，日本女性乳腺癌的生物学行为最近也在发生变化。时间趋势数据清楚地表明，未来日本的乳腺癌将更类似于西方，而且如今它已经在西化。
