Oriente P, Riccio A, Farinaro C, Scarpa R, De Marco F, Giardina M G, Gentile R, Prantera T, Del Puente A
Boll Soc Ital Biol Sper. 1984 Mar 30;60(3):641-7.
20 free aminoacids levels have been measured with a chromatographic method (Beckman 118 BL Aminoacid analyzer) in 9 patients affected by progressive systemic sclerosis and in 15 healthy subjects (control group). Both patients and control group were females, mean daily protein intake was between 1,2-1,5 gr/Kg in the two groups. No other pathological condition was found in each patient, none of them was receiving drug therapy at least from 2 months. No significant age different existed between the patients and the control group. Analysis of variance of the results showed significant decreases of proline, histidine, valine and methionine levels and significant increase of aspartic acid concentration in the plasma of PSS patients.
采用色谱法（贝克曼118 BL氨基酸分析仪）测定了9例进行性系统性硬化症患者和15名健康受试者（对照组）的20种游离氨基酸水平。患者组和对照组均为女性，两组的平均每日蛋白质摄入量均在1.2 - 1.5克/千克之间。每位患者均未发现其他病理状况，至少2个月内均未接受药物治疗。患者组和对照组之间不存在显著的年龄差异。结果的方差分析显示，进行性系统性硬化症患者血浆中的脯氨酸、组氨酸、缬氨酸和蛋氨酸水平显著降低，天冬氨酸浓度显著升高。
