普齐地洛与普萘洛尔对静息及运动时肾脏血流动力学影响的比较。
Comparison of the effects of prizidilol and propranolol on renal haemodynamics at rest and during exercise.
作者信息
Malini P L, Strocchi E, Ambrosioni E
出版信息
Br J Clin Pharmacol. 1984 Mar;17(3):251-5. doi: 10.1111/j.1365-2125.1984.tb02339.x.
Abstract
Effective renal plasma flow and glomerular filtration rate were measured in 22 mild-to-moderate, uncomplicated, essential hypertensive patients during placebo and after 3 months of randomly assigned treatment either with prizidilol (n = 10) or propranolol (n = 12). Measurements were performed at rest and during cycloergometer exercise. For a comparable effect on blood pressure effective renal plasma flow was significantly increased at rest by prizidilol (+9%) and decreased by propranolol (-13.6%); these patterns were maintained during exercise. Glomerular filtration rate was immodified after the treatment with both drugs. It is concluded that prizidilol is an effective hypotensive agent with no deleterious effects on renal haemodynamics.
摘要
在22例轻度至中度、无并发症的原发性高血压患者中，测量了安慰剂期以及随机分配接受普齐地洛（n = 10）或普萘洛尔（n = 12）治疗3个月后的有效肾血浆流量和肾小球滤过率。测量在静息状态和蹬车运动期间进行。为了对血压产生可比的效应，普齐地洛使静息时有效肾血浆流量显著增加（+9%），而普萘洛尔使其降低（-13.6%）；这些模式在运动期间得以维持。两种药物治疗后肾小球滤过率均未改变。得出的结论是，普齐地洛是一种有效的降压药，对肾血流动力学无有害影响。
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本文引用的文献
1
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2
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Eur J Clin Pharmacol. 1980 Aug;18(2):175-83. doi: 10.1007/BF00561587.
3
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4
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5
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