拉贝洛尔和普萘洛尔长期治疗后的肾血流动力学
Renal haemodynamics after chronic treatment with labetalol and propranolol.
作者信息
Malini P L, Strocchi E, Negroni S, Ambrosioni E, Magnani B
出版信息
Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):123S-126S. doi: 10.1111/j.1365-2125.1982.tb01900.x.
Abstract
1 Effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) were measured in two groups of 12 patients both at rest and during sub-maximal cycloergometer exercise while on placebo and after 3 months of treatment with either labetalol or propranolol. 2 ERPF increased and renal vascular resistance decreased both at rest and during exercise after labetalol treatment, compared with placebo; the opposite was observed after propranolol treatment. 3 GFR increased after labetalol and decreased after propranolol both at rest and during exercise, compared with placebo, but these changes were not statistically significant. 4 Labetalol and propranolol resulted in the same decrease in blood pressure and a comparable incidence of side effects.
摘要
- 在两组各12例患者中，于静息状态及次极量蹬车运动期间，在服用安慰剂时以及在用拉贝洛尔或普萘洛尔治疗3个月后，测量了有效肾血浆流量（ERPF）和肾小球滤过率（GFR）。2. 与安慰剂相比，拉贝洛尔治疗后，静息及运动时ERPF均增加，肾血管阻力降低；普萘洛尔治疗后则观察到相反情况。3. 与安慰剂相比，拉贝洛尔治疗后静息及运动时GFR增加，普萘洛尔治疗后GFR降低，但这些变化无统计学意义。4. 拉贝洛尔和普萘洛尔导致的血压下降幅度相同，副作用发生率相当。
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