银屑病中安替比林清除率的降低。
Reduction of antipyrine clearance in psoriasis.
作者信息
Marsden J R, Williams F M, Keys B, Rawlins M D, Shuster S
出版信息
Br J Clin Pharmacol. 1984 Mar;17(3):331-3. doi: 10.1111/j.1365-2125.1984.tb02349.x.
Antipyrine clearance was determined in 41 psoriatics and age-sex matched controls, using sequential measurements of salivary concentration. Antipyrine clearance and elimination rate constant were less in psoriatics (P less than 0.05) and apparent volumes of distribution were similar. These differences were greater between female psoriatics and controls (P less than 0.025; P less than 0.05) and the differences between male psoriatics and controls were not significant. Correlation of simultaneous measurements of saliva and plasma antipyrine concentration in six psoriatics and age-sex matched controls showed no differences between the two groups. We conclude that antipyrine clearance is reduced in psoriasis but the underlying mechanism is unclear.
通过对唾液浓度进行连续测量，测定了41例银屑病患者及年龄、性别匹配的对照组的安替比林清除率。银屑病患者的安替比林清除率和消除速率常数较低（P<0.05），分布容积相似。女性银屑病患者与对照组之间的这些差异更大（P<0.025；P<0.05），男性银屑病患者与对照组之间的差异不显著。对6例银屑病患者及年龄、性别匹配的对照组同时测量唾液和血浆中的安替比林浓度，结果显示两组之间无差异。我们得出结论，银屑病患者的安替比林清除率降低，但其潜在机制尚不清楚。
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