食物对人体中氯苯氧基异丁酸对氯酚酯吸收的影响。
Influence of food on the absorption of the p-chlorophenolic ester of chlorophenoxyisobutyric acid in man.
作者信息
Houin G, Shastri R A, Barre J, Pinchon B, Tillement J P
出版信息
Br J Clin Pharmacol. 1984 Mar;17(3):341-5. doi: 10.1111/j.1365-2125.1984.tb02351.x.
A study was designed to investigate the effect of a fatty meal on the absorption of chlorophenoxyisobutyric acid (CPIB) in six healthy adult volunteers after oral administration of the p-chlorophenolic (PCP) ester of CPIB. Plasma concentrations of CPIB when administered with food were higher than those observed in the fasting state. The Cmax in the former case was 24.0 +/- 4.6 mg l-1 as against a value of 15.2 +/- 6.9 mg l-1 in the latter (P less than 0.01). The pharmacokinetic parameters measured were found to be linear with the dose administered. This could be due to low plasma concentrations of CPIB unable to cause a saturation of the plasma protein binding of this drug. It is concluded that a fatty meal enhances the absorption of this hypolipidaemic drug.
一项研究旨在调查在六名健康成年志愿者口服氯苯氧基异丁酸（CPIB）的对氯酚酯（PCP）后，一顿高脂餐对CPIB吸收的影响。与食物一起服用时，CPIB的血浆浓度高于空腹状态下观察到的浓度。前一种情况下的Cmax为24.0±4.6mg l-1，而后一种情况的值为15.2±6.9mg l-1（P<0.01）。发现所测量的药代动力学参数与给药剂量呈线性关系。这可能是由于CPIB的血浆浓度较低，无法导致该药物的血浆蛋白结合饱和。得出的结论是，一顿高脂餐可增强这种降血脂药物的吸收。
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