Dumont A E, Martelli A B, Schinella R A
Br J Exp Pathol. 1984 Apr;65(2):155-63.
The transected colon was studied in rats in an attempt to determine whether the regenerating cut ends could be induced to lengthen by delaying or preventing their spontaneous reattachment. When the two cut ends of the defunctionalized colon were separated by a 2-3-cm length of silastic tubing mucosal, luminal and serosal continuity across the gap was restored in 8-10 weeks. Cannulation of one cut end with silastic tubing so placed as to extend 2-3 cm beyond the cut end led to lengthening of the intestine over the exposed end of the tubing by 20 weeks. The area subadjacent to regenerated mucosa filled initially with granulation tissue which was gradually replaced by loose connective tissue containing at times a thin layer of smooth muscle.
在大鼠身上对横断的结肠进行了研究，以确定是否可以通过延迟或阻止其自发重新附着来诱导再生的断端延长。当失功能结肠的两个断端被一段2 - 3厘米长的硅橡胶管隔开时，8 - 10周内间隙处的黏膜、管腔和浆膜连续性得以恢复。用硅橡胶管对一个断端进行插管，使其超出断端2 - 3厘米，20周后肠管在暴露的管端上方延长。再生黏膜下方的区域最初充满肉芽组织，逐渐被含有一层薄平滑肌的疏松结缔组织所取代。
