Rutanen E M, Koistinen R, Wahlström T, Sjöberg J, Stenman U H, Seppälä M
Br J Obstet Gynaecol. 1984 Apr;91(4):377-81. doi: 10.1111/j.1471-0528.1984.tb05927.x.
Placental protein 12 (PP12) was measured by radio-immuno-assay in serum and endometrial extracts of 25 women at various phases of the menstrual cycle, and in the decidua from six women undergoing legal abortion in early pregnancy. The results were analysed with respect to endometrial histology and serum oestradiol, progesterone and PP12 concentrations. PP12 was detected in the secretory phase endometrium and decidua, but not in the proliferative phase endometrium. The PP12 concentration in tissue increased from early (1.3-9.4 micrograms/g protein) to late secretory phase (5.3-155 micrograms/g), and considerably higher levels were found in decidua (282-3846 micrograms/g). There was a correlation (P less than 0.001) between endometrial PP12 and serum progesterone levels in non-pregnant women, and there also was a slight correlation (P less than 0.05) between endometrial and serum PP12 concentrations. These results show that PP12 is not pregnancy specific and suggest that the occurrence of PP12 is dependent on progesterone.
采用放射免疫分析法测定了25名处于月经周期不同阶段的女性血清和子宫内膜提取物中的胎盘蛋白12（PP12），以及6名早期妊娠行合法流产女性的蜕膜中的PP12。结合子宫内膜组织学以及血清雌二醇、孕酮和PP12浓度对结果进行了分析。PP12在分泌期子宫内膜和蜕膜中被检测到，但在增殖期子宫内膜中未被检测到。组织中的PP12浓度从分泌早期（1.3 - 9.4微克/克蛋白质）到分泌晚期（5.3 - 155微克/克）升高，且在蜕膜中发现的水平要高得多（282 - 3846微克/克）。非妊娠女性子宫内膜PP12与血清孕酮水平之间存在相关性（P < 0.001），子宫内膜和血清PP12浓度之间也存在轻微相关性（P < 0.05）。这些结果表明PP12并非妊娠特异性的，并提示PP12的出现依赖于孕酮。
