Wahlström T, Seppälä M
Fertil Steril. 1984 May;41(5):781-4. doi: 10.1016/s0015-0282(16)47851-9.
The occurrence of PP12 was studied by the biotin-avidin immunoperoxidase method in the endometrium of 106 premenopausal and postmenopausal women at various phases of the menstrual cycle or during estrogen and progestogen replacement therapy. No PP12 was found in the endometrium under the following conditions: (1) during the proliferative phase, (2) in cystic glandular hyperplasia, (3) during the first 3 postovulatory days in ovulatory cycles, (4) in atrophic postmenopausal endometrium, and (5) in estrogen-stimulated postmenopausal endometrium. PP12 was found in the endometrium under the following conditions: (1) in the secretory endometrium from the fourth postovulatory day onward, (2) in the endometrium during progestogen treatment of previously anovulatory premenopausal women, and (3) in the endometrium from postmenopausal women treated with estrogen followed by combined estrogen and progestogen replacement therapy. These results suggest that PP12 is a P-dependent protein which, in natural cycles, appears in the endometrium around the time of implantation and, in postmenopausal women, can be induced by progestogens after estrogen priming.
采用生物素-抗生物素蛋白免疫过氧化物酶法，对106例处于月经周期不同阶段或接受雌激素和孕激素替代治疗的绝经前和绝经后妇女的子宫内膜进行研究，以观察PP12的出现情况。在以下情况下，子宫内膜中未发现PP12：（1）增殖期；（2）囊性腺性增生；（3）排卵周期排卵后前3天；（4）绝经后萎缩性子宫内膜；（5）雌激素刺激的绝经后子宫内膜。在以下情况下，子宫内膜中发现了PP12：（1）排卵后第4天起的分泌期子宫内膜；（2）既往无排卵的绝经前妇女接受孕激素治疗期间的子宫内膜；（3）接受雌激素治疗后再接受雌激素和孕激素联合替代治疗的绝经后妇女的子宫内膜。这些结果表明，PP12是一种依赖孕激素的蛋白，在自然周期中，它在着床期左右出现在子宫内膜中，在绝经后妇女中，雌激素预处理后孕激素可诱导其出现。
