Sandusky G E, Capen C C, Kerr K M
Can J Comp Med. 1984 Jan;48(1):81-6.
Described are pathological studies of eight dogs which died in congestive heart failure, with a clinical diagnosis of congestive cardiomyopathy. Examination revealed marked dilatation and enlargement of all four chambers of the heart. The ventricular walls were thin with small atrophic papillary muscles. Histological studies on the myocardium revealed scattered areas of myocardial necrosis, especially around the papillary muscles of the left ventricle and random scattered areas of fibrosis. Electron microscopic studies revealed fewer and disoriented myofibrils, myocytolysis, increased numbers of mitochondria with swelling and inclusions, increased glycogen granules and increased numbers of lysosomes, lipofuscin granules and lipid droplets. Mild Z-band abnormalities were found throughout the myofibers.
描述了八只死于充血性心力衰竭的犬的病理学研究，临床诊断为充血性心肌病。检查发现心脏的所有四个腔室均明显扩张和增大。心室壁薄，乳头肌萎缩。心肌组织学研究显示散在的心肌坏死区域，尤其是左心室乳头肌周围，以及随机散在的纤维化区域。电子显微镜研究显示肌原纤维数量减少且排列紊乱、肌细胞溶解、线粒体数量增加且肿胀并有内含物、糖原颗粒增加、溶酶体、脂褐素颗粒和脂滴数量增加。在整个肌纤维中发现轻度Z带异常。
