Dessì S, Batetta B, Laconi E, Ennas C, Pani P
Chem Biol Interact. 1984 Mar;48(3):271-9. doi: 10.1016/0009-2797(84)90140-6.
Wistar rats treated with lead nitrate were used in these experiments to provide evidence of the possible correlation between hyperplasia, induced cholesterol synthesis and the levels of glucose-6-phosphate dehydrogenase (G-6-PD) in the liver. Lead treatment increases liver weight, hepatic cholesterol esters and the relative content of free cholesterol. An increase of the incorporation of tritiated water in free and cholesterol esters was also observed. The effect of lead resulted in an increase of hepatic G-6-PD at all times considered. The correlation between these parameters and hyperplasia are discussed.
在这些实验中，使用用硝酸铅处理的Wistar大鼠来提供肝脏中增生、诱导胆固醇合成与葡萄糖-6-磷酸脱氢酶（G-6-PD）水平之间可能存在的相关性的证据。铅处理会增加肝脏重量、肝脏胆固醇酯以及游离胆固醇的相对含量。还观察到氚水掺入游离胆固醇酯和胆固醇酯中的量有所增加。在所有考虑的时间点，铅的作用都会导致肝脏G-6-PD增加。讨论了这些参数与增生之间的相关性。
