Dessì S, Chiodino C, Batetta B, Fadda A M, Anchisi C, Pani P
Exp Mol Pathol. 1986 Apr;44(2):169-76. doi: 10.1016/0014-4800(86)90067-5.
Liver regeneration after partial hepatectomy was used as an experimental model for studying mammalian cell division and replication. The rate of cell proliferation in this hyperplastic model was correlated with hepatic de novo synthesis of cholesterol, with the hexose monophosphate shunt pathway of glucose metabolism, and with serum lipoproteins. An increase of hepatic cholesterol esters and of incorporation of tritiated water in cholesterol esters was observed at 24 hr after partial hepatectomy. Partial hepatectomy also resulted in an increase of hepatic glucose-6-phosphate dehydrogenase and in alteration of serum lipoproteins, primarily due to a selective decline in high density lipoprotein fraction.
部分肝切除术后的肝脏再生被用作研究哺乳动物细胞分裂和复制的实验模型。在这个增生模型中，细胞增殖速率与肝脏胆固醇的从头合成、葡萄糖代谢的磷酸己糖旁路途径以及血清脂蛋白相关。部分肝切除术后24小时观察到肝脏胆固醇酯增加以及氚标记水掺入胆固醇酯中。部分肝切除还导致肝脏葡萄糖-6-磷酸脱氢酶增加以及血清脂蛋白改变，主要是由于高密度脂蛋白部分选择性下降。
