Shepherd J P, Dawber R P
Cryobiology. 1984 Apr;21(2):157-69. doi: 10.1016/0011-2240(84)90207-4.
There are many references in the surgical literature to apparent lack of scarring after cryosurgery. This has been investigated experimentally by comparing the effects on the skin of four freeze-thaw schedules commonly used in clinical practice with those of maximal cryosurgical injury. Absence of damage to collagen is described, and it is proposed that this is an important factor in the often cited lack of scarring. Changes in skin thickness over a 6-month period are described, and obvious scarring after severe injury and long-term dermis thinning after less severe injury are reported. Evidence is presented that epidermal cells and fibroblasts differ in their susceptibility to low-temperature damage.
外科文献中有许多关于冷冻手术后明显无瘢痕形成的记载。通过比较临床实践中常用的四种冻融方案对皮肤的影响与最大冷冻手术损伤的影响，对此进行了实验研究。文中描述了对胶原蛋白无损伤的情况，并提出这是经常被提及的无瘢痕形成的一个重要因素。还描述了6个月期间皮肤厚度的变化，并报告了严重损伤后明显的瘢痕形成以及较轻损伤后长期的真皮变薄情况。有证据表明，表皮细胞和成纤维细胞对低温损伤的敏感性不同。
