Shepherd J P, Dawber R P
Plast Reconstr Surg. 1982 Dec;70(6):677-82. doi: 10.1097/00006534-198212000-00003.
The effectiveness of cryosurgery in the treatment of a series of keloid scars in 17 patients has been investigated. A portable liquid nitrogen spray was used, and cryosurgical schedules shown experimentally to produce minimal scarring in normal skin were utilized in order to minimize recurrence rate. Temperatures achieved were monitored using digital thermometers, and scar volumes before and 1 month after treatment were calculated from plaster impressions. Response to treatment was poor, only two scars exhibiting marked reduction in volume without further, more severe freezing. Calculations of an accurate recurrence rate were impossible because of this poor response, but both earlobe keloids responded well and showed no evidence of recurrence at 1 year. Results provide further evidence that lesions made up principally of fibrous tissue respond poorly to cryosurgery.
研究了冷冻手术治疗17例患者一系列瘢痕疙瘩的疗效。使用便携式液氮喷雾，并采用经实验证明在正常皮肤中产生最小瘢痕的冷冻手术方案，以尽量降低复发率。使用数字温度计监测达到的温度，并根据石膏模型计算治疗前和治疗后1个月的瘢痕体积。治疗效果不佳，只有两个瘢痕体积明显减小，且未进行进一步更深度的冷冻。由于反应不佳，无法准确计算复发率，但两个耳垂瘢痕疙瘩反应良好，1年后未显示复发迹象。结果提供了进一步的证据，表明主要由纤维组织构成的病变对冷冻手术反应不佳。
