大鼠肝脏形成的大麻二酚单羟基化代谢产物的鉴定。
Identification of monohydroxylated metabolites of cannabidiol formed by rat liver.
作者信息
Martin B, Nordqvist M, Agurell S, Lindgren J E, Leander K, Binder M
出版信息
J Pharm Pharmacol. 1976 Apr;28(4):275-9. doi: 10.1111/j.2042-7158.1976.tb04152.x.
Cannabidiol (CBD) was metabolized in vitro by rat liver enzymes. Unchanged CBD and eight monohydroxylated metabolites were isolated and positively identified. As previously reported, 7-hydroxy-CBD was the major metabolite. The second most abundant metabolite was 6alpha-hydroxy-CBD; whereas only a trace amount of 6beta-hydroxy-CBD was found. In addition hydroxylation occurred in all positions of the pentyl side chain, 4 inches-hydroxy-CBD being most abundant. 3 inches-Hydroxy-CBD was formed in half of the yield of 4 inches-hydroxy-CBD, while 1 inches-, 2 inches-, 5 inches-hydroxy-CBD were each formed in approximately one fourth of the yield of 4 inches-hydroxy-CBD.
大麻二酚（CBD）在体外被大鼠肝脏酶代谢。分离并确证了未变化的CBD和8种单羟基化代谢物。如先前报道，7-羟基-CBD是主要代谢物。第二丰富的代谢物是6α-羟基-CBD；而仅发现痕量的6β-羟基-CBD。此外，戊基侧链的所有位置均发生羟基化，4″-羟基-CBD最为丰富。3″-羟基-CBD的生成量为4″-羟基-CBD的一半，而1″-、2″-、5″-羟基-CBD的生成量各自约为4″-羟基-CBD的四分之一。
Zotero 插件