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大麻素戊基侧链的微生物氧化

Microbiological oxidation of the pentyl side chain of cannabinoids.

作者信息

Robertson L W, Koh S W, Huff S R, Malhotra R K, Ghosh A

出版信息

Experientia. 1978 Aug 15;34(8):1020-2. doi: 10.1007/BF01915321.

DOI:10.1007/BF01915321
PMID:700011
Abstract

Syncephalastrum racemosum ATCC 18192 and Mycobacterium rhodochrous ATCC 19067 partially degrade the n-pentyl side chain of cannabidiol, cannabinol, delta8-tetrahydrocannabinol and delta9-tetrahydrocannabinol. Carboxylic acid and alcohol side chain derivatives are major metabolites.

摘要

总状共头霉ATCC 18192和红串红球菌ATCC 19067可部分降解大麻二酚、大麻酚、δ8-四氢大麻酚和δ9-四氢大麻酚的正戊基侧链。羧酸和醇侧链衍生物是主要代谢产物。

相似文献

1
Microbiological oxidation of the pentyl side chain of cannabinoids.大麻素戊基侧链的微生物氧化
Experientia. 1978 Aug 15;34(8):1020-2. doi: 10.1007/BF01915321.
2
Oxidative cleavage of the pentyl side-chain of cannabinoids. Identification of new biotransformation pathways in the metabolism of 4'-hydroxy-delta-9-tetrahydrocannabinol in the mouse.大麻素戊基侧链的氧化裂解。小鼠体内4'-羟基-δ-9-四氢大麻酚代谢中新生物转化途径的鉴定。
Drug Metab Dispos. 1990 May-Jun;18(3):350-5.
3
Synthesis and characterization of glucuronides of Cannabinol, cannabidiol, delta9-tetrahydrocannabinol and delta8-tetrahydrocannabinol.大麻酚、大麻二酚、Δ9-四氢大麻酚和Δ8-四氢大麻酚葡糖醛酸苷的合成与表征
Biomed Mass Spectrom. 1977 Jun;4(3):190-6. doi: 10.1002/bms.1200040313.
4
Metabolites of cannabidiol identified in human urine.在人类尿液中鉴定出的大麻二酚代谢物。
Xenobiotica. 1990 Mar;20(3):303-20. doi: 10.3109/00498259009046849.
5
Further studies on the oxidative cleavage of the pentyl side-chain of cannabinoids: identification of new biotransformation pathways in the metabolism of 3'-hydroxy-delta-9-tetrahydrocannabinol by the mouse.大麻素戊基侧链氧化裂解的进一步研究：小鼠对3'-羟基-δ-9-四氢大麻酚代谢中新生物转化途径的鉴定
Xenobiotica. 1989 Dec;19(12):1437-47. doi: 10.3109/00498258909043194.
6
Delta9-THC as a discriminative cue in pigeons: effects of delta8-THC, CBD, and CBN.Δ9-四氢大麻酚作为鸽子的辨别性线索：Δ8-四氢大麻酚、大麻二酚和大麻酚的影响。
Arch Int Pharmacodyn Ther. 1977 Jul;228(1):68-72.
7
Instability and poor recovery of cannabinoids in urine, oral fluid, and hair.尿液、口腔液和毛发中大麻素的稳定性及回收率较差。
Forensic Sci Rev. 2018 Jan;30(1):33-49.
8
Chromatographic separation of cannabinoids and their monooxygenated derivatives.大麻素及其单加氧衍生物的色谱分离
J Chromatogr. 1976 May 26;120(2):334-8.
9
Effects of cannabinoids on L1210 murine leukemia. 1. Inhibition of DNA synthesis.
Res Commun Chem Pathol Pharmacol. 1977 Aug;17(4):703-14.
10
Mass spectrometry of cannabinoids.大麻素的质谱分析。
J Pharm Sci. 1977 Oct;66(10):1444-50. doi: 10.1002/jps.2600661025.

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本文引用的文献

1
Transformations of cannabinol in the mouse.小鼠体内大麻酚的转化
Res Commun Chem Pathol Pharmacol. 1975 Jul;11(3):343-54.
2
Microbiological transformation of cannabinoids.大麻素的微生物转化
Experientia. 1977 Jun 15;33(6):718-20. doi: 10.1007/BF01944147.
3
Biotransformation of cannabidiol in mice. Identification of new acid metabolites.
Drug Metab Dispos. 1977 May-Jun;5(3):259-67.
大麻二酚的人体代谢产物：关于其形成、生物活性及治疗相关性的综述
Cannabis Cannabinoid Res. 2016 Mar 1;1(1):90-101. doi: 10.1089/can.2015.0012. eCollection 2016.
4
In vitro stability of free and glucuronidated cannabinoids in urine following controlled smoked cannabis.经控制吸烟大麻后尿液中游离和结合型大麻素的体外稳定性。
Anal Bioanal Chem. 2014 Jan;406(3):785-92. doi: 10.1007/s00216-013-7524-7. Epub 2013 Dec 1.
5
Hydroxylation and further oxidation of delta9-tetrahydrocannabinol by alkane-degrading bacteria.烷烃降解菌对大麻二酚的羟化和进一步氧化。
Appl Environ Microbiol. 2009 Nov;75(22):7135-41. doi: 10.1128/AEM.01277-09. Epub 2009 Sep 18.
6
Metabolism of cannabidiol by the rat.
Eur J Drug Metab Pharmacokinet. 1991 Oct-Dec;16(4):305-13. doi: 10.1007/BF03189976.
7
Microbiological transformations of nabilone, a synthetic cannabinoid.合成大麻素那必隆的微生物转化
Appl Environ Microbiol. 1979 May;37(5):965-71. doi: 10.1128/aem.37.5.965-971.1979.
4
Dioxygenated metabolites of cannabidiol formed by rat liver.
J Pharm Pharmacol. 1976 Aug;28(8):603-8. doi: 10.1111/j.2042-7158.1976.tb02809.x.
5
Identification of new in vivo side-chain acid metabolites of delta1-tetrahydrocannabinol.Δ¹-四氢大麻酚新的体内侧链酸代谢物的鉴定
J Pharm Pharmacol. 1976 Oct;28(10):773-4. doi: 10.1111/j.2042-7158.1976.tb04047.x.
6
Identification of monohydroxylated metabolites of cannabidiol formed by rat liver.大鼠肝脏形成的大麻二酚单羟基化代谢产物的鉴定。
J Pharm Pharmacol. 1976 Apr;28(4):275-9. doi: 10.1111/j.2042-7158.1976.tb04152.x.