Deutsch S, Krumholz B, Benjamin I
J Reprod Med. 1978 May;20(5):275-82.
Fourteen patients with clinically diagnosed and surgically documented polycystic ovarian (Stein-Leventhal) disease (PCOD) and 16 normal control women were studied to identify the laboratory test or tests that, from the clinician's point of view, are most likely to aid in the nonsurgical diagnosis of the disease. A single random morning blood specimen was assayed in all cases for testosterone, epitestosterone, androstenedione, FSH and LH. The mean testosterone level for the PCOD patients was significantly greater (p less than 0.001) than that for the controls, with 50% of the patients showing elevated levels. Androstenedione showed a similar pattern, but mean epitestosterone levels were not significantly different from controls. FSH was not significantly different, but LH levels were significantly higher than controls (p less than 0.005), with 10 of 13 (77%) demonstrating elevated levels. A strong positive correlation was also found between the degree of virilization and the levels of LH, testosterone and androstenedione. This study suggests that the most useful diagnostic laboratory assay from a single drawing of blood is the serum LH; the only other useful test is testosterone and/or androstenedione. These data do not support other reports of elevated levels of epitestosterone or decreased values of FSH in PCOD.
对14例临床诊断并经手术证实为多囊卵巢（斯坦因-莱文塔尔）病（PCOD）的患者以及16名正常对照女性进行了研究，以确定从临床医生的角度来看，最有助于该病非手术诊断的一项或多项实验室检查。所有病例均采集单次随机晨尿血标本，检测睾酮、表睾酮、雄烯二酮、促卵泡激素（FSH）和促黄体生成素（LH）。PCOD患者的平均睾酮水平显著高于对照组（p<0.001），50%的患者睾酮水平升高。雄烯二酮呈现类似模式，但平均表睾酮水平与对照组无显著差异。FSH无显著差异，但LH水平显著高于对照组（p<0.005），13例中有10例（77%）LH水平升高。同时还发现男性化程度与LH、睾酮和雄烯二酮水平之间存在强正相关。该研究表明，单次采血最有用的诊断性实验室检测是血清LH；唯一其他有用的检测是睾酮和/或雄烯二酮。这些数据不支持其他关于PCOD中表睾酮水平升高或FSH值降低的报道。
