Milanov M P, Stoyanov I N, Boev K K
Gen Pharmacol. 1984;15(2):99-105. doi: 10.1016/0306-3623(84)90090-9.
In the majority of experiments the ruminal preparations did not exhibit spontaneous electrical and contractile activity but showed a Ca-dependent spike-free myogenic tone. Ba2+ or Sr2+ evoked spike activity and phasic contractions and increased the muscle tonic tension. Tetraethylammonium (TEA) exerted no effect on the ruminal preparations but potentiated the effect of Ba2+. Acetylcholine (ACh) induced dose-dependent spike-free tonic contractions which were verapamil resistant and were suppressed by sodium nitroprusside. When applied to BaCl2- or TEA-pretreated preparations ACh caused spike activity and phasic contractions. The antral abomasum exhibited a spontaneous electrical activity--slow waves on which spike potentials were superimposed. ACh and TEA induced membrane depolarization and increased the spike activity and the phasic contraction amplitude.
在大多数实验中，瘤胃制剂未表现出自发的电活动和收缩活动，但呈现出依赖钙的无峰肌源性张力。Ba2+或Sr2+诱发峰电位活动和相性收缩，并增加肌肉张力。四乙铵（TEA）对瘤胃制剂无作用，但增强了Ba2+的作用。乙酰胆碱（ACh）诱导剂量依赖性的无峰张力性收缩，该收缩对维拉帕米耐药且被硝普钠抑制。当应用于BaCl2或TEA预处理的制剂时，ACh引起峰电位活动和相性收缩。皱胃窦表现出自发电活动——叠加有峰电位的慢波。ACh和TEA诱导膜去极化，并增加峰电位活动和相性收缩幅度。
