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电场刺激后绵羊复杂胃平滑肌条的神经递质介导反应

Neurotransmitted responses of smooth-muscle strips of complex sheep stomach after electrical field stimulation.

作者信息

Vassileva P, Stoyanov I, Loukanov Y

出版信息

Acta Physiol Pharmacol Bulg. 1978;4(1):11-8.

PMID:726911
Abstract

Contractile responses to stimulation of nerve elements in smooth-muscle strips of complex sheep stomach suggest the existence of inhibitory and excitatory nerve structures in preparations from all compartments. Pharmacological analysis of the responses shows that they are mediated by cholinergic excitatory, noncholinergic excitatory and nonadrenergic inhibitory nerve elements. Comparison of the distribution of the cholinergic nerve structures shows that there are no essential differences between the different compartments. Differences are observed between strips cut in the direction of the two muscle layers, the effect of the cholinergic nerve elements being more pronounced in the longitudinal strips compared with the transverse ones. Noncholinergic excitatory effects of nerve stimulation are observed in all compartments of the complex stomach. Nonadrenergic nerve structures with inhibitory effect on the muscle strips are found in all compartments of the stomach. It is assumed that in the rumen they have spontaneous activity which inhibits the capacity of the smooth muscles in this part of the stomach for spontaneous phasic contractions.

摘要

对复杂羊胃平滑肌条中神经元件刺激的收缩反应表明,来自所有腔室的制剂中存在抑制性和兴奋性神经结构。对这些反应的药理学分析表明,它们由胆碱能兴奋性、非胆碱能兴奋性和非肾上腺素能抑制性神经元件介导。胆碱能神经结构分布的比较表明,不同腔室之间没有本质区别。在沿两个肌肉层方向切割的条带之间观察到差异,与横向条带相比,胆碱能神经元件在纵向条带中的作用更明显。在复杂胃的所有腔室中均观察到神经刺激的非胆碱能兴奋作用。在胃的所有腔室中均发现对肌肉条具有抑制作用的非肾上腺素能神经结构。据推测,在瘤胃中它们具有自发活动,可抑制胃这一部分平滑肌的自发相性收缩能力。

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