Petelenz T, Axenti I, Petelenz T J, Iwiński J, Dubel S
Int J Clin Pharmacol Ther Toxicol. 1984 Mar;22(3):152-5.
Findings are reported on a prototype mini set for iontophoresis used to topically anesthetise the puncture spot before injection. The anesthetizing drug applied was a 2% solution of lignocaine which was iontophoresed for 10 min at a current of 1-2.5 mA. Observations were made according to a double-blind trial. After the lignocaine iontophoresis had been performed, 76% of injections were painless and 24% were reported painful. After the placebo iontophoresis, however, 87% of injections were painful. The difference is statistically significant. We conclude that iontophoresis by means of the mini set protects effectively against injection pain. The electronic structure of the device is unique and makes possible safe outpatient use.
报告了一种用于离子电渗疗法的微型原型装置的研究结果，该装置用于在注射前对穿刺点进行局部麻醉。所使用的麻醉药物是2%的利多卡因溶液，以1-2.5毫安的电流进行离子电渗10分钟。观察是根据双盲试验进行的。在进行利多卡因离子电渗后，76%的注射无痛，24%的注射有疼痛感。然而，在进行安慰剂离子电渗后，87%的注射有疼痛感。差异具有统计学意义。我们得出结论，通过该微型装置进行的离子电渗能有效防止注射疼痛。该装置的电子结构独特，使得门诊安全使用成为可能。
