采用自动气相色谱法测定血浆中的可卡因。
Determination of cocaine in plasma by automated gas chromatography.
作者信息
Jacob P, Elias-Baker B A, Jones R T, Benowitz N L
出版信息
J Chromatogr. 1984 Mar 9;306:173-81. doi: 10.1016/s0378-4347(00)80880-4.
PMID:6715457
Abstract
A rapid and sensitive gas chromatographic method is described for the determination of cocaine in plasma. A close structural analogue of cocaine, m-toluylecgonine methyl ester, is used as an internal standard. The simplicity of the extraction scheme and the use of an automatic sampler makes the method convenient for large numbers of samples generated in pharmacokinetic studies.
摘要
本文描述了一种快速灵敏的气相色谱法，用于测定血浆中的可卡因。可卡因的一种结构类似物间甲苯酰芽子碱甲酯用作内标。提取方案的简便性以及自动进样器的使用，使得该方法便于处理药代动力学研究中产生的大量样品。
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