Holdsworth D G, Roberts M S, Polack A E
J Clin Hosp Pharm. 1984 Mar;9(1):29-39. doi: 10.1111/j.1365-2710.1984.tb00916.x.
The disappearance of chlorbutol from aqueous solutions stored in polyethylene containers under various experimental and simulated patient use conditions is described. Chlorbutol is lost by sorption into the container wall, container insert and by permeation into the external environment. The extent of chlorbutol loss from solution and uptake by the container components is dependent on temperature, chlorbutol concentration and the closure used. Aqueous chlorbutol solutions stored in the polyethylene container evaluated have a predicted shelf-life (time for 10% loss) of about 4 months at 25 degrees C and 8 months at 20 degrees C. Negligible loss is found during simulated patient use over 1 month.
描述了在各种实验和模拟患者使用条件下，储存在聚乙烯容器中的水溶液中三氯叔丁醇的消失情况。三氯叔丁醇通过吸附到容器壁、容器内插件以及渗透到外部环境中而损失。溶液中三氯叔丁醇的损失程度以及容器组件的吸收程度取决于温度、三氯叔丁醇浓度和所使用的密封盖。在所评估的聚乙烯容器中储存的三氯叔丁醇水溶液，在25℃时预计保质期（损失10%的时间）约为4个月，在20℃时为8个月。在超过1个月的模拟患者使用期间，发现损失可忽略不计。
