Tromovitch T A, Stegman S J, Glogau R G
J Am Acad Dermatol. 1984 Feb;10(2 Pt 1):273-8. doi: 10.1016/s0190-9622(84)70036-3.
This paper describes in detail the injection technics for Zyderm collagen, purified bovine collagen (EPC), presently used by us. Because we were clinical investigators, we have used the material for longer than 6 years. The paper outlines our initial technics, some of which were successful and some, not successful. Equipment, patient positioning, technics for estimating whether or not EPC will work, syringe and needle positioning, and how best to judge whether or not the implant is being placed in the dermis are discussed. Each indication for EPC and each area where EPC is effective are addressed individually, with special emphasis on the precise technic that produces the best and longest-lasting results. Because we feel that injection technic is critical for safety and efficacy, this detailed description of the technic and how it was derived is submitted for others to share.
本文详细描述了我们目前使用的Zy derm胶原蛋白（纯化牛胶原蛋白，EPC）的注射技术。由于我们是临床研究人员，使用该材料已超过6年。本文概述了我们最初的技术，其中一些成功了，一些则未成功。讨论了设备、患者体位、评估EPC是否有效的技术、注射器和针头的定位，以及如何最好地判断植入物是否置于真皮层。针对EPC的每种适应症以及EPC有效的每个区域分别进行了阐述，特别强调了能产生最佳和最持久效果的精确技术。因为我们认为注射技术对安全性和有效性至关重要，所以提交了对该技术及其推导过程的详细描述，以供他人参考。
