Injectable collagen: a clinical overview.

Injectable bovine collagen is extremely effective in the correction of contour defects of the skin due to scarring and age-induced rhytides and folds. The rate of adverse reactions is low. Of 5,109 patients treated in clinical trials, 1.3 percent experienced temporary local inflammation at the site of injection. Techniques of injection and proper patient selection are presented. Repeat implantations at intervals of six to twenty-four months are often required to maintain full correction of cutaneous contour defects.