Emmanuel B, Kennelly J J
J Dairy Sci. 1984 Feb;67(2):344-50. doi: 10.3168/jds.S0022-0302(84)81307-7.
Propionic acid was used as a possible preventive agent against ketogenesis. A total of 12 Suffolk lactating sheep were allocated to groups of 4 and fed isocaloric isonitrogenous rations containing 0, 5 and 10% propionic acid for 2 wk at 1.25 kg twice daily, followed by 4 days of food restriction to .5 kg/day and 2 days of food deprivation to induce ketogenesis. During the restricted feeding, concentrations of glucose in blood plasma were higher (50 to 57 versus 41 to 53 mg/dl) and concentrations of D (--)-3-hydroxybutyrate and acetoacetate lower (3.0 to 5.9 versus 3.9 to 7.6 mg/dl; .39 to .83 versus .43 to .92 mg/dl) in animals fed propionic acid. Propionic acid did not change free fatty acid concentrations of blood plasma or milk and subcutaneous fatty acid composition. Restricted feeding and fasting markedly lowered glucose and elevated concentrations of ketone bodies and free fatty acids in plasma. Furthermore, during these periods proportions of milk fatty acids containing 4 to 14 carbon atoms were decreased and those of stearic and oleic acid (18:0 and 18:1) were increased (16.6 versus 6.5%; and 41.0 versus 17.4%).
丙酸被用作一种可能预防生酮作用的药剂。总共12只萨福克泌乳母羊被分成4只一组，每天两次以1.25千克的量饲喂含0%、5%和10%丙酸的等热量等氮日粮，持续2周，随后4天限制采食量至0.5千克/天，并禁食2天以诱导生酮作用。在限饲期间，饲喂丙酸的动物血浆中葡萄糖浓度较高（50至57对41至53毫克/分升），而D（-）-3-羟基丁酸和乙酰乙酸浓度较低（3.0至5.9对3.9至7.6毫克/分升；0.39至0.83对0.43至0.92毫克/分升）。丙酸并未改变血浆游离脂肪酸浓度、乳脂肪酸组成或皮下脂肪酸组成。限饲和禁食显著降低了血浆中的葡萄糖水平，提高了酮体和游离脂肪酸的浓度。此外，在这些时期，含4至14个碳原子的乳脂肪酸比例降低，而硬脂酸和油酸（18:0和18:1）的比例升高（16.6%对6.5%；41.0%对17.4%）。
