Pchelkina A A, Medvedeva G I
J Hyg Epidemiol Microbiol Immunol. 1984;28(1):41-52.
Strains of tick-borne encephalitis virus isolated in the natural foci of infection in the eastern part of the Russian Plain (the Kirov region) were examined for their biological properties. The strains examined were 69 strains isolated from ticks Ixodes persulcatus, 62 strains obtained from patients with the clinically manifest form of tick-borne encephalitis and 56 strains isolated from the blood of patients with the inapparent form of infection. Comparative studies on laboratory animals (albino mice, golden hamsters, suckling guinea pigs and other mammals) as well as comparative serologic studies provided evidence which suggested that all virus isolates from the Kirov region were antigenically identical with the strain "Sofin" isolated in the Far East and represent thus a single causative agent of the tick-borne encephalitis virus infection. This strain of virus is supposed to exist in two variants, in dependence on ecological conditions: one of these variants is the eastern variant (strain Sofin and strains from the Kirov region) and the other one is the western variant of tick-borne encephalitis virus.
对在俄罗斯平原东部（基洛夫地区）感染自然疫源地分离出的蜱传脑炎病毒株进行了生物学特性检测。检测的毒株包括从全沟硬蜱分离出的69株、从临床显性蜱传脑炎患者获得的62株以及从隐性感染患者血液中分离出的56株。对实验动物（白化小鼠、金黄仓鼠、乳豚鼠和其他哺乳动物）的比较研究以及比较血清学研究提供的证据表明，基洛夫地区分离出的所有病毒株在抗原性上与在远东分离出的“Sofin”株相同，因此代表蜱传脑炎病毒感染的单一病原体。根据生态条件，这种病毒株被认为存在两种变体：其中一种变体是东部变体（Sofin株和基洛夫地区的毒株），另一种是蜱传脑炎病毒的西部变体。
