腺病毒12型基因401在转化感染中的功能。
Adenovirus type 12 gene 401 function in transforming infection.
作者信息
Ledinko N
出版信息
J Virol. 1978 Jun;26(3):828-31. doi: 10.1128/JVI.26.3.828-831.1978.
Abstract
The temperature-sensitive DNA-minus mutant, H12ts401, transformed two to eight times more hamster embryo cells than wild-type 12 adenovirus at 38.5 degrees C, but was unable to establish transformation of cultures of hamster embryo brain and rat 3Y1 cells at 41.5 and 40 degrees C, respectively. Another H12ts406 DNA-minus mutant was not defective in cell transformation at these restrictive temperatures. Both mutants, however, induced T-antigen and cell DNA synthesis after infection of 3Y1 cells at 40 degrees C.
摘要
温度敏感型DNA缺失突变体H12ts401在38.5摄氏度时转化仓鼠胚胎细胞的能力比野生型12型腺病毒高两到八倍，但在41.5摄氏度和40摄氏度时分别无法在仓鼠胚胎脑细胞培养物和大鼠3Y1细胞中建立转化。另一个H12ts406 DNA缺失突变体在这些限制温度下细胞转化方面没有缺陷。然而，这两种突变体在40摄氏度感染3Y1细胞后均诱导了T抗原和细胞DNA合成。
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引用本文的文献
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Adenovirus type 12 gene 401 function and maintenance of transformation.腺病毒12型基因401的功能与转化维持
J Virol. 1979 Jan;29(1):250-60. doi: 10.1128/JVI.29.1.250-260.1979.
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