Boer G J, Kruisbrink J
J Endocrinol. 1984 May;101(2):121-9. doi: 10.1677/joe.0.1010121.
A controlled-delivery module based on microporous Accurel polypropylene tubing, implanted subcutaneously in the rat, was used to release oxytocin for at least 40 days both in vitro and in vivo. Using a dosage rate of approximately 650 ng oxytocin per day and implanting the device in rats on day 17 of pregnancy, the known physiological action of oxytocin in advancing labour was confirmed. The increased concentrations of oxytocin in the mothers gave rise to adverse effects; the course of labour was protracted during expulsions of the first pups and the birth weight was reduced. Postnatally, body development of the pups was also affected, although there was partial recovery when the pups started to feed independently. Both pre- and postnatal exposure of pups to an oxytocin-treated mother reduced their body water turnover measured at 1 month of age. The effects on the course of parturition and during lactation might be explained by a blockade of uterine and mammary gland oxytocin receptors respectively, thereby inhibiting a proper response to pulsatile endogenous oxytocin secretion. The changes in water metabolism, which are opposite to those described for the heterologous hormone vasopressin, are less easy to explain since maternal oxytocin is not supposed to pass the placenta. The results may indicate that clinical use of oxytocin for induction of labour and lactation may have hitherto unrecognized side-effects.
一种基于微孔Accurel聚丙烯管的控释模块，皮下植入大鼠体内，用于在体外和体内释放催产素至少40天。以每天约650 ng催产素的剂量给药，并在妊娠第17天将该装置植入大鼠体内，证实了催产素在促进分娩方面的已知生理作用。母体中催产素浓度的增加产生了不良影响；在第一只幼崽排出期间分娩过程延长，出生体重降低。产后，幼崽的身体发育也受到影响，不过当幼崽开始独立进食时会有部分恢复。幼崽在出生前和出生后暴露于接受催产素治疗的母体，均会降低其1月龄时测量的身体水分周转率。对分娩过程和哺乳期的影响可能分别是由于子宫和乳腺催产素受体被阻断，从而抑制了对脉动性内源性催产素分泌的正常反应。水代谢的变化与针对异源激素血管加压素所描述的变化相反，不太容易解释，因为母体催产素被认为不会穿过胎盘。结果可能表明，催产素在引产和促进泌乳方面的临床应用可能存在迄今未被认识到的副作用。
