Magnusson G, Melin P
Arch Toxicol. 1985 Sep;57(4):246-9. doi: 10.1007/BF00324786.
The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth retardation of the pups, that the growth inhibiting effect was directly correlated to the length of administration and that the growth inhibiting effect was more pronounced if dEtOT was given close to parturition than if it was given earlier in the pregnancy. In addition, the growth retardation was not due to an effect on the pups but to an effect on their mothers, probably related to inhibition of the emptying mechanisms of the mammary glands, meaning that the pups were insufficiently fed by their mothers immediately after birth.
在两项实验中，研究了1-去氨基-2-酪氨酰（乙基）催产素（dEtOT）在妊娠第15天至分娩日给药时对大鼠围产期和产后发育的影响。研究表明，dEtOT对出生时的幼崽没有影响，dEtOT导致幼崽出现剂量相关的生长迟缓，生长抑制作用与给药时间长短直接相关，并且如果在临近分娩时给予dEtOT，其生长抑制作用比在妊娠早期给药时更明显。此外，生长迟缓不是由于对幼崽的影响，而是由于对其母亲的影响，可能与乳腺排空机制的抑制有关，这意味着幼崽出生后立即没有得到母亲足够的喂养。
