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精神分裂症中特定注意力缺陷的临床及病因学意义

Clinical and etiological implications of a specific attention deficit in schizophrenia.

作者信息

Spaulding W, Huntzinger R S, LeCompte P, Cromwell R L

出版信息

J Nerv Ment Dis. 1984 May;172(5):279-86. doi: 10.1097/00005053-198405000-00005.

Abstract

Forty-seven psychiatric inpatients, including 26 schizophrenics and 21 nonschizophrenics, were measured on four clinical factors (chronicity, premorbid adjustment, reported symptomatology, and diagnosis) and four indices of reaction time (RT) performance (mean RT, RT variance, and redundancy-associated deficit [RAD] at 3- and 7-second preparatory intervals [PIs] ). Each clinical factor was analyzed in turn as a dependent variable in multiple regression analyses. The RT indices comprised the predictor set in each multiple regression. RAD at 7-second PI is related to chronicity for psychiatric patients in general and for schizophrenic patients in particular. Diagnosis and premorbid adjustment are related primarily to mean RT. No evidence was found that RAD is an artifact of high intertrial variance or long RT latencies, but intertrial variance does play a role in moderating the implications of RAD. The different correlations within schizophrenic and nonschizophrenic groups suggest a) that the Elgin Scale has a different meaning when used with schizophrenics than with nonschizophrenics, and b) that it is not useful to treat schizophrenic and nonschizophrenic disorders on the same continuum. The results in general suggest that the vulnerability factor thought to be associated with RAD militates for greater chronicity across different types of patients. The RAD effect within schizophrenics is nevertheless relatively greater than within other patients.

摘要

47名精神科住院患者,包括26名精神分裂症患者和21名非精神分裂症患者,接受了四项临床因素(病程、病前适应、报告的症状学和诊断)以及四项反应时间(RT)表现指标(平均RT、RT方差以及在3秒和7秒准备间隔[PI]时的冗余相关缺陷[RAD])的测量。在多元回归分析中,依次将每个临床因素作为因变量进行分析。RT指标构成了每次多元回归中的预测变量集。总体而言,对于精神科患者,尤其是精神分裂症患者,7秒PI时的RAD与病程相关。诊断和病前适应主要与平均RT相关。没有证据表明RAD是试验间高方差或长RT潜伏期的人为产物,但试验间方差确实在调节RAD的影响方面发挥了作用。精神分裂症组和非精神分裂症组内不同的相关性表明:a)与非精神分裂症患者相比,埃尔金量表用于精神分裂症患者时具有不同的含义;b)在同一连续体上治疗精神分裂症和非精神分裂症障碍是没有用的。总体结果表明,被认为与RAD相关的脆弱性因素在不同类型的患者中导致了更高的病程。然而,精神分裂症患者中的RAD效应相对大于其他患者。

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