Harrow M, Marengo J, McDonald C
Schizophr Bull. 1986;12(2):208-24. doi: 10.1093/schbul/12.2.208.
The current investigation studied the early course of positive thought disorder and its relationship to other aspects of schizophrenic outcome. Forty-eight schizophrenics diagnosed using the Research Diagnostic Criteria (RDC), 51 psychotic nonschizophrenics, and 67 nonpsychotic patients were studied at index hospitalization and at a 1.5-year followup. Most thought-disordered schizophrenics and other psychotic patients showed some reduction in thought pathology between index hospitalization and followup (p less than .02). A larger percentage of schizophrenics than other psychotic and nonpsychotic showed thought disorder at the acute phase and at followup assessment (p less than .05), although only a subgroup of 27 percent of the schizophrenics showed severe thought disorder at followup. At followup, severely thought-disordered schizophrenics showed residual signs of psychosis and poor functioning in other areas. Positive thought disorder in schizophrenics at followup most often occurred within the context of an unremitted illness and was less frequently due to a new, acute episode of disturbance. Continuously thought-disordered schizophrenics exhibited more severe impairments in life adjustment at 1.5-year followup than did episodic or nonthought-disordered schizophrenics (p less than .02). The results suggest that severe thought disorder is a persistent characteristic in a subgroup of early schizophrenics.
当前的调查研究了阳性思维障碍的早期病程及其与精神分裂症预后其他方面的关系。使用研究诊断标准（RDC）诊断的48名精神分裂症患者、51名非精神分裂症性精神病患者和67名非精神病患者在首次住院时及1.5年随访时接受了研究。大多数思维紊乱的精神分裂症患者和其他精神病患者在首次住院和随访之间思维病理学有一定程度的减轻（p<0.02）。与其他精神病患者和非精神病患者相比，更大比例的精神分裂症患者在急性期和随访评估时表现出思维障碍（p<0.05），尽管只有27%的精神分裂症患者亚组在随访时表现出严重的思维障碍。在随访时，思维严重紊乱的精神分裂症患者表现出精神病残留症状，且在其他方面功能较差。随访时精神分裂症患者的阳性思维障碍最常出现在疾病未缓解的情况下，较少是由于新的急性发作性紊乱。在1.5年随访时，持续思维紊乱的精神分裂症患者在生活适应方面比发作性或无思维紊乱的精神分裂症患者表现出更严重的损害（p<0.02）。结果表明，严重的思维障碍是早期精神分裂症患者亚组的一个持续特征。
