Taylor A, Talner L B, Davis G
J Urol. 1978 Aug;120(2):142-4. doi: 10.1016/s0022-5347(17)57080-9.
The relative renal accumulation of 99mtechnetium penicillamine was evaluated as an index of differential renal function. Regions of interest were assigned over each kidney with a computer and the renal uptake of 99mtechnetium penicillamine was determined. A simple background correction was made by subtracting the renal activity at 10 minutes from that at 25 minutes. The percentage of 99mtechnetium penicillamine accumulation in the left kidney was correlated with the percentage of the total effective renal plasma flow to the left kidney. Effective renal plasma flow was determined after the intravenous injection of 131 I hippuran using a highly sophisticated computerized technique that has been validated in patients by comparison with traditional split renal function studies. The correlation coefficient between the 2 measurements was 0.97. In addition to its use as an index of differential effective renal plasma flow 99mtechnetium penicillamine is an excellent cortical imaging agent and the relative distribution of 99mtechnetium penicillamine between the 2 kidneys and within a single kidney can be assessed qualitatively by visual inspection of the scan.
将99m锝青霉胺的相对肾摄取量作为鉴别肾功能的指标进行评估。用计算机在每个肾脏上划定感兴趣区，测定99m锝青霉胺的肾脏摄取量。通过用25分钟时的肾脏活性减去10分钟时的肾脏活性进行简单的本底校正。左肾中99m锝青霉胺的蓄积百分比与左肾总有效肾血浆流量的百分比相关。在静脉注射131I马尿酸后，采用一种高度精密的计算机技术测定有效肾血浆流量，该技术已通过与传统的分肾功能研究相比较在患者中得到验证。这两项测量之间的相关系数为0.97。除了用作鉴别有效肾血浆流量的指标外，99m锝青霉胺还是一种出色的皮质显像剂，通过对扫描图像进行目视检查，可以定性评估99m锝青霉胺在两肾之间以及单个肾脏内的相对分布。
