Yoshikawa N, Hashimoto H, Katayama Y, Yamada Y, Matsuo T, Okada S
J Pathol. 1984 Apr;142(4):253-7. doi: 10.1002/path.1711420403.
To determine the specificity and significance of widespread attenuation of the glomerular basement membrane on electron microscopy, 240 renal biopsies from 218 children were studied retrospectively. Twenty-three patients showed diffuse attenuation and three of them are cases of hereditary nephritis. The other 20 patients are characterized by persistent microscopic haematuria, absence of proteinuria, normal blood pressure and renal function, and minimal glomerular changes. In 10 of these 20 children, microscopic haematuria was also present in the family. We conclude that widespread attenuation of the glomerular basement membrane is a characteristic of benign familial and non-familial haematuria. The thin glomerular basement membrane may be responsible for the haematuria and may result from incomplete glomerular maturation.
为了确定肾小球基底膜广泛变薄在电子显微镜下的特异性及意义，我们对218名儿童的240份肾活检标本进行了回顾性研究。23例患者表现为弥漫性变薄，其中3例为遗传性肾炎。另外20例患者的特点是持续镜下血尿、无蛋白尿、血压及肾功能正常，肾小球改变轻微。在这20名儿童中，有10名儿童的家族成员也存在镜下血尿。我们得出结论，肾小球基底膜广泛变薄是良性家族性和非家族性血尿的特征。薄肾小球基底膜可能是血尿的原因，可能是由于肾小球成熟不完全所致。
