Yoshikawa N, Ito H, Nakahara C, Yoshiara S, Yoshiya K, Matsuo T, Hasegawa O, Hazikano H, Okada S
Virchows Arch A Pathol Anat Histopathol. 1985;406(1):33-43. doi: 10.1007/BF00710555.
An electron-microscopic study of the glomeruli was made on 154 children with IgA nephropathy and no evidence of systemic disease, in whom immunofluorescence microscopy had shown diffuse mesangial deposition of IgA. Mesangial deposits were observed in all but eight children. Subepithelial deposits were observed in 40 children and were almost always accompanied by both mesangial and subendothelial deposits. Subepithelial deposits were significantly associated with more severe clinical presentations, a worse outcome and more severe light microscopic glomerular changes. These observations support the concept that IgA nephropathy is an immune complex disease.
对154例无全身性疾病证据的IgA肾病患儿的肾小球进行了电子显微镜研究，这些患儿的免疫荧光显微镜检查显示IgA在系膜区弥漫性沉积。除8例患儿外，其余患儿均观察到系膜沉积物。40例患儿观察到上皮下沉积物，且几乎总是伴有系膜和内皮下沉积物。上皮下沉积物与更严重的临床表现、更差的预后以及更严重的光镜下肾小球改变显著相关。这些观察结果支持IgA肾病是一种免疫复合物疾病的概念。
