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Deaza analogues of adenosine as inhibitors of blood platelet aggregation.

作者信息

Antonini I, Cristalli G, Franchetti P, Grifantini M, Martelli S, Petrelli F

出版信息

J Pharm Sci. 1984 Mar;73(3):366-9. doi: 10.1002/jps.2600730319.

DOI:10.1002/jps.2600730319
PMID:6716245
Abstract

A number of deaza analogues of adenosine were prepared and tested as inhibitors of platelet aggregation induced by ADP and collagen to investigate the structure-activity relationships in this class of nucleoside analogues. The results showed that the presence of a 6-amino group and nitrogen atoms at positions 3 and 7 of the purine moiety are required for inhibitory activity.

摘要

相似文献

1
Deaza analogues of adenosine as inhibitors of blood platelet aggregation.
J Pharm Sci. 1984 Mar;73(3):366-9. doi: 10.1002/jps.2600730319.
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J Lab Clin Med. 1976 Apr;87(4):703-9.

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The stereoselective enzymatic synthesis of 9-beta-D-2'-deoxyribofuranosyl 1-deazapurine.9-β-D-2'-脱氧呋喃核糖基-1-脱氮嘌呤的立体选择性酶促合成。
Nucleic Acids Res. 1989 Jun 12;17(11):4217-22. doi: 10.1093/nar/17.11.4217.