Samet J M, Kutvirt D M, Waxweiler R J, Key C R
N Engl J Med. 1984 Jun 7;310(23):1481-4. doi: 10.1056/NEJM198406073102301.
We performed a population-based case-control study to examine the association between uranium mining and lung cancer in Navajo men, a predominantly nonsmoking population. The 32 cases included all those occurring among Navajo men between 1969 and 1982, as ascertained by the New Mexico Tumor Registry. For each case in a Navajo man, two controls with nonrespiratory cancer were selected. Of the 32 Navajo patients, 72 per cent had been employed as uranium miners, whereas no controls had documented experience in this industry. The lower 95 per cent confidence limit for the relative risk of lung cancer associated with uranium mining was 14.4. Information on cigarette smoking was available for 21 of the 23 affected uranium miners; eight were nonsmokers and median consumption by the remainder was one to three cigarettes daily. These results demonstrate that in a rural nonsmoking population most of the lung cancer may be attributable to one hazardous occupation.
我们开展了一项基于人群的病例对照研究，以检验纳瓦霍族男性（主要为非吸烟人群）中铀矿开采与肺癌之间的关联。32例病例包括新墨西哥肿瘤登记处确定的1969年至1982年间纳瓦霍族男性中发生的所有肺癌病例。对于每一例纳瓦霍族男性肺癌病例，选取两名患非呼吸道癌症的对照者。在32名纳瓦霍族患者中，72%曾受雇为铀矿矿工，而对照者中无人有该行业工作经历的记录。与铀矿开采相关的肺癌相对风险的95%置信区间下限为14.4。在23名受影响的铀矿矿工中，有21人的吸烟信息可用；8人不吸烟，其余人的日均吸烟量中位数为1至3支。这些结果表明，在农村非吸烟人群中，大部分肺癌可能归因于一种危险职业。
