Lerchen M L, Wiggins C L, Samet J M
Interdepartmental Program in Epidemiology, University of New Mexico School of Medicine, Albuquerque 87131.
J Natl Cancer Inst. 1987 Oct;79(4):639-45.
The association between occupation and lung cancer risk was examined in a population-based, case-control study of 506 patients (333 males and 173 females) and 771 control (499 males and 272 females) subjects in New Mexico. A personal interview was used to obtain lifetime occupational and smoking histories and self-reported history of exposures to specific agents. High-risk jobs were identified in advance of data analysis and linked with industrial and occupational codes for hypothesis testing. For females, lung cancer risk was not associated with employment history, but power was limited. For males, elevated risks were found for the uranium mining industry [odds ratio (OR) = 1.9; 95% confidence internal (CI) = 0.8-4.9], underground miners (OR = 2.1; 95% CI = 1.1-3.7), painters (OR = 2.7; 95% CI = 0.8-8.9), and welders (OR = 3.2; 95% CI = 1.4-7.4). For self-reported exposure to any of 18 agents, only the OR for exposure to "other metals" was elevated. The population attributable risk in males was estimated as 14% for employment in any high-risk industry or occupation with an OR above 1 in this study.
在新墨西哥州开展的一项基于人群的病例对照研究中，对506例患者（333例男性和173例女性）和771名对照者（499例男性和272例女性）进行了职业与肺癌风险之间关联的研究。通过个人访谈获取终生职业和吸烟史以及自我报告的特定物质接触史。在数据分析之前确定高危工作，并将其与行业和职业编码相关联以进行假设检验。对于女性，肺癌风险与就业史无关，但检验效能有限。对于男性，发现铀矿开采行业（比值比[OR]=1.9；95%可信区间[CI]=0.8-4.9）、地下矿工（OR=2.1；95%CI=1.1-3.7）、油漆工（OR=2.7；95%CI=0.8-8.9）和焊工（OR=3.2；95%CI=1.4-7.4）的风险升高。对于自我报告的18种物质中的任何一种接触情况，仅接触“其他金属”的OR升高。在本研究中，男性从事任何OR高于1的高危行业或职业的人群归因风险估计为14%。
