Boucher M, Dubray C, Duchêne-Marullaz P
Naunyn Schmiedebergs Arch Pharmacol. 1984 Feb;325(2):183-5. doi: 10.1007/BF00506199.
The chronotropic effects of pindolol were studied in the conscious dog with chronic A-V block. Pindolol significantly increased atrial rate, probably through both its strong intrinsic sympathomimetic activity and reflex withdrawal of atrial vagal tone in response to its hypotensive effect. Pindolol did not alter ventricular rate overall. However, in individual dogs, pindolol caused ventricular chronotropic effects that were inversely related to resting ventricular rate: it increased ventricular rate when the resting ventricular rate was low and reduced it when it was high. In view of the fact that pindolol is a beta-adrenoceptor antagonist endowed with a strong intrinsic sympathomimetic activity, this finding contributes to a better understanding of how pindolol affects heart rate.
在患有慢性房室传导阻滞的清醒犬中研究了吲哚洛尔的变时作用。吲哚洛尔显著增加心房率，这可能是由于其强大的内在拟交感活性以及因降压作用引起的心房迷走神经张力反射性减退。吲哚洛尔总体上未改变心室率。然而，在个别犬中，吲哚洛尔引起的心室变时作用与静息心室率呈负相关：静息心室率低时它增加心室率，静息心室率高时则降低心室率。鉴于吲哚洛尔是一种具有强大内在拟交感活性的β肾上腺素能受体拮抗剂，这一发现有助于更好地理解吲哚洛尔如何影响心率。
