Hulsebosch C E, Perez-Polo J R, Coggeshall R E
Neurosci Lett. 1984 Jan 27;44(1):19-23. doi: 10.1016/0304-3940(84)90214-3.
Dorsal root unmyelinated axons in 30-day-old rats in which the spinal cord has been hemisected at birth are more numerous on the operated side in animals that receive preimmune serum daily from hemisection to sacrifice. This is interpreted as indicating that sprouting of sensory axons occurred on the operated side. In animals with hemisected cords treated daily with antibodies to nerve growth factor (anti-NGF), the same numbers of unmyelinated axons are found in the roots on the operated side, but there are even more unmyelanated axons on the unoperated side. Our interpretation is that anti-NGF results in sensory axon sprouting with more sprouts on the unoperated side. Thus removal of NGF in cord hemisected newborn rats has an effect on sensory axon numbers.
在出生时脊髓已被半横切的30日龄大鼠中，从半横切到处死每天接受免疫前血清的动物，其手术侧背根无髓鞘轴突数量更多。这被解释为表明感觉轴突在手术侧发生了发芽。在每天用神经生长因子抗体（抗NGF）处理半横切脊髓的动物中，手术侧神经根中发现的无髓鞘轴突数量相同，但未手术侧的无髓鞘轴突更多。我们的解释是，抗NGF导致感觉轴突发芽，未手术侧的芽更多。因此，在新生大鼠脊髓半横切后去除NGF对感觉轴突数量有影响。
