Duff P, Huff R W, Gibbs R S
Obstet Gynecol. 1984 May;63(5):697-702.
One hundred thirty-four indigent patients at term who had premature rupture of membranes and a cervix unfavorable for induction of labor (80% effacement or less, 2 cm dilation or less) were randomized to compare expectant with intervention management. Women with any medical or obstetric condition warranting immediate intervention were excluded from the study. Patients treated expectantly were placed at bed rest and observed for labor or infection. Patients managed by intervention were given oxytocin if labor did not ensue within 12 hours of rupture of the membranes. Patients in the intervention protocol had longer labor (P less than .02) and a higher incidence of both cesarean delivery (P less than .05) and intraamniotic infection (P less than .05). There was only one case of proven neonatal sepsis, and this occurred in a patient managed by induction of labor. There was no statistically significant difference between groups in mean length of maternal hospitalization.
134名足月贫困患者，胎膜早破且宫颈条件不利于引产（宫颈管消退80%或以下，宫口扩张2cm或以下），被随机分组以比较期待治疗和干预治疗。患有任何需要立即干预的内科或产科疾病的女性被排除在研究之外。接受期待治疗的患者卧床休息，观察是否临产或发生感染。接受干预治疗的患者如果在胎膜破裂12小时内未临产，则给予缩宫素。干预组患者产程更长（P<0.02），剖宫产（P<0.05）和羊膜腔内感染（P<0.05）的发生率更高。仅1例确诊为新生儿败血症，发生在引产治疗的患者中。两组产妇平均住院时间无统计学差异。
