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氯尼达明与头颈癌放疗:一项初步研究

Lonidamine and radiotherapy in head and neck cancers. A pilot study.

作者信息

Magno L, Terraneo F, Ciottoli G B

出版信息

Oncology. 1984;41 Suppl 1:113-5. doi: 10.1159/000225898.

DOI:10.1159/000225898
PMID:6717889
Abstract

The tolerance and antitumor activity of Lonidamine combined with radiotherapy were studied on 40 patients with head and neck cancer and compared with a historical control group. Lonidamine was well tolerated. 26 and 17 complete responses were seen in the Lonidamine-treated group and in the historical control group, respectively.

摘要

对40例头颈癌患者研究了氯尼达明联合放疗的耐受性和抗肿瘤活性,并与一个历史对照组进行比较。氯尼达明耐受性良好。氯尼达明治疗组和历史对照组分别观察到26例和17例完全缓解。

相似文献

1
Lonidamine and radiotherapy in head and neck cancers. A pilot study.氯尼达明与头颈癌放疗:一项初步研究
Oncology. 1984;41 Suppl 1:113-5. doi: 10.1159/000225898.
2
Double-blind randomized study of lonidamine and radiotherapy in head and neck cancer.
Int J Radiat Oncol Biol Phys. 1994 Apr 30;29(1):45-55. doi: 10.1016/0360-3016(94)90225-9.
3
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Potentiation of radiation effects on multicellular tumor spheroids (MTS) of HeLa cells by lonidamine.
Int J Radiat Oncol Biol Phys. 1989 May;16(5):1277-80. doi: 10.1016/0360-3016(89)90298-8.
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The combined use of radiation therapy and lonidamine in the treatment of brain metastases.放射治疗与氯尼达明联合用于脑转移瘤的治疗。
J Neurooncol. 1989 Sep;7(3):241-7. doi: 10.1007/BF00172917.
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Lonidamine alone and in combination with other chemotherapeutic agents in the treatment of cancer patients.氯尼达明单独及与其他化疗药物联合用于癌症患者的治疗。
Oncology. 1984;41 Suppl 1:108-12. doi: 10.1159/000225897.
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Radiosensitization of Meth-A fibrosarcoma in mice by Lonidamine.氯尼达明对小鼠Meth-A纤维肉瘤的放射增敏作用
Oncology. 1984;41 Suppl 1:36-8. doi: 10.1159/000225883.
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Combination of chemotherapy with radiotherapy: review of previous studies and new perspectives.
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Phase I toxicologic study of Lonidamine in cancer patients.氯尼达明在癌症患者中的I期毒理学研究。
Oncology. 1984;41 Suppl 1:56-9. doi: 10.1159/000225887.
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Phase II study of lonidamine in inoperable non-small-cell lung cancer.氯尼达明治疗不可切除非小细胞肺癌的II期研究。
Oncology. 1984;41 Suppl 1:86-9. doi: 10.1159/000225893.

引用本文的文献

1
Lonidamine Induced Selective Acidification and De-Energization of Prostate Cancer Xenografts: Enhanced Tumor Response to Radiation Therapy.氯尼达明诱导前列腺癌异种移植瘤的选择性酸化和去能化:增强肿瘤对放射治疗的反应。
Cancers (Basel). 2024 Mar 31;16(7):1384. doi: 10.3390/cancers16071384.
2
Mechanism of antineoplastic activity of lonidamine.氯尼达明的抗肿瘤活性机制。
Biochim Biophys Acta. 2016 Dec;1866(2):151-162. doi: 10.1016/j.bbcan.2016.08.001. Epub 2016 Aug 4.
3
Reviving Lonidamine and 6-Diazo-5-oxo-L-norleucine to Be Used in Combination for Metabolic Cancer Therapy.
重新启用氯尼达明和6-重氮-5-氧代-L-正亮氨酸联合用于代谢性癌症治疗。
Biomed Res Int. 2015;2015:690492. doi: 10.1155/2015/690492. Epub 2015 Sep 6.
4
Phase II study of lonidamine in metastatic breast cancer.氯尼达明治疗转移性乳腺癌的II期研究。
Br J Cancer. 1989 Feb;59(2):251-3. doi: 10.1038/bjc.1989.51.
5
The combined use of radiation therapy and lonidamine in the treatment of brain metastases.放射治疗与氯尼达明联合用于脑转移瘤的治疗。
J Neurooncol. 1989 Sep;7(3):241-7. doi: 10.1007/BF00172917.
6
Effect of lonidamine on the cytotoxicity of four alkylating agents in vitro.
Cancer Chemother Pharmacol. 1989;25(1):32-6. doi: 10.1007/BF00694335.