Holland C
Parasitology. 1984 Apr;88 ( Pt 2):303-15.
Rats harbouring a 35-day-old primary infection of Moniliformis dubius were inoculated with constant doses of Nippostrongylus brasiliensis and 10 days later, after post mortem examination, rats with concurrent infections harboured significantly fewer Nippostrongylus than rats with single infections. Similar infections of Moniliformis were carried out, but with post mortem taking place on days 8, 9, 12 and 14 of the Nippostrongylus infections. On days 8 and 9 of infection, rats with concurrent infections did not harbour significantly fewer Nippostrongylus compared with single infections. Both single and concurrent infections of 12- and 14-day-old Nippostrongylus were found to harbour lower numbers of worms. In the single infection this corresponds to the timing of the typical immune expulsion of a primary single infection which takes place on approximately day 12 of infection. The Moniliformis population was not significantly affected, in terms of numbers, dry weight and length, although each parasite population did show a slight shift in site in the presence of the other. A significant reduction in egg production by Nippostrongylus was detected throughout concurrent infection. The possible role of non-reciprocal cross-immunity is discussed as an explanation for the apparent early expulsion of the Nippostrongylus population in the presence of Moniliformis.
给感染念珠棘虫35天的大鼠接种恒定剂量的巴西日圆线虫，10天后进行尸检，结果发现，同时感染两种寄生虫的大鼠体内巴西日圆线虫的数量明显少于单一感染的大鼠。进行了类似的念珠棘虫感染实验，但在感染巴西日圆线虫的第8、9、12和14天进行尸检。在感染的第8天和第9天，同时感染两种寄生虫的大鼠体内巴西日圆线虫的数量与单一感染的大鼠相比并无显著减少。在感染12天和14天的大鼠中，单一感染和同时感染的巴西日圆线虫数量均较少。在单一感染中，这与原发性单一感染典型免疫排斥的时间相对应，大约在感染后第12天发生。尽管在另一种寄生虫存在的情况下，每种寄生虫群体在寄生部位确实出现了轻微变化，但念珠棘虫群体在数量、干重和长度方面并未受到显著影响。在整个同时感染过程中，检测到巴西日圆线虫的产卵量显著减少。文中讨论了非相互交叉免疫的可能作用，以此解释在存在念珠棘虫的情况下，巴西日圆线虫群体明显提前被排斥的现象。
