Laury M C, Azma F, Zizine L, Portet R
Pflugers Arch. 1984 Feb;400(2):171-7. doi: 10.1007/BF00585035.
The aim of this work was to test the role of pituitary dependent hormones in cold-induced non-shivering thermogenesis. In the 28 degrees C-acclimated rat, hypophysectomy inhibited body growth and led to an atrophy of thyroid and adrenals. In brown adipose tissue (BAT) some alterations were induced which are usually observed after cold acclimation of the animal: increase in relative weight, decreases in the relative amount of lipids, increases in the amounts of protein and DNA and modification of the proportions of several phospholipid fatty acids; moreover, basal lipolysis, in vitro, was enhanced to the same extent as that following cold acclimation of the normal rat. The in vivo stimulation by norepinephrine (NE) of O2 consumption (test for nonshivering thermogenesis) and of fatty acid release into blood were suppressed. Progressive cold acclimation of the hypophysectomized rats at 15 degrees C led to a hypertrophy of BAT to the same extent as in the sham-operated animals. The in vivo sensitivity to NE was partially restored. The results suggest that hypophysectomy does not suppress the ability to acclimate to moderate cold by means of BAT dependent non-shivering thermogenesis. However, the low ability to produce heat seems to indicate that pituitary or pituitary-dependent hormones are necessary to optimize the cold stimulation of brown fat thermogenesis.
这项工作的目的是测试垂体依赖性激素在冷诱导的非寒战产热中的作用。在适应28摄氏度的大鼠中，垂体切除会抑制身体生长，并导致甲状腺和肾上腺萎缩。在棕色脂肪组织（BAT）中，会诱导出一些通常在动物冷适应后观察到的变化：相对重量增加、脂质相对含量减少、蛋白质和DNA含量增加以及几种磷脂脂肪酸比例的改变；此外，体外基础脂解作用增强到与正常大鼠冷适应后相同的程度。去甲肾上腺素（NE）对耗氧量（非寒战产热测试）和脂肪酸释放到血液中的体内刺激作用受到抑制。将垂体切除的大鼠在15摄氏度下进行渐进性冷适应，会导致BAT肥大，程度与假手术动物相同。对NE的体内敏感性部分恢复。结果表明，垂体切除并不抑制通过BAT依赖性非寒战产热来适应中度寒冷的能力。然而，产热能力较低似乎表明垂体或垂体依赖性激素对于优化棕色脂肪产热的冷刺激是必要 的。
